Laboratory Instruments / Bioprinters Cellink

Bioprinter BIO X

Meet the BIO X

Laboratory Instruments

The future of medicine has never been so close to us

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Innovative methods for the engineering of human tissues and organs can have a significant impact on the future of medicine. 3D bioprinting is considered a revolutionary technology to push and accelerate progress in tissue engineering and regenerative medicine.
3D bioprinting therefore represents the future of medicine, we believe we can create this future through a spirit of collaboration and by putting all our experiences at the service of humanity.
The future is created in the present and belongs to those who act, to those who keep going forward to see their visions come true.

BIO X is the most user-friendly and flexible bioprinter in the world, providing the user with an unparalleled bioprinting experience. The built-in features along with the new BIO X software managed through the large touchscreen display minimize the learning curve and ensure you will receive the results you want.
Bioprinted tissue can be used in drug discovery where researchers can test new potential treatments and evaluate efficacy in very early stages. New drugs and treatments will potentially reach clinical trials faster with a decreased number of failures and reduced need for animal testing.
BIO X is the next generation bioprinter, bringing scientists closer to the future of medicine.

Discover the benefits

Clean, reinvented

A complete system of uncompromised cleanliness

With dual high-power fans producing a powerful airflow through its dual-filtration top, BIO X bioprinter creates a positive pressure inside the chamber. The HEPA H14 dual-filter top retains more than 99.995% of unwanted particles and microorganisms. BIO X is equipped with UV-C germicidal lamps that allow you to run automatic cycles to sterilize the printing environment.

Printheads

Intelligent and exchangeable

BIO X is the first 3D bioprinter in the world with Intelligent Printheads (iPH), ensuring your research is always on the cutting edge. BIO X printheads are designed with flexibility, beauty and simplicity in mind. The best part is that you can design your own dispensing technologies or methods to use with BIO X system. The possibilities are endless, giving you full freedom in your lab work.

Wide material range

Unfit material? Not with a heat-controlled print bed

BIO X allows you to delicately control the temperature of its print bed, enabling a new level of printing quality. Being able to control the print bed temperature paves the way for using any bioink, no matter the viscosity.

Bioprinter BIO X

Bioprinter BIO X

Testimonianze

Giorgia Montalbano, Giulia Molino, Sonia Fiorilli, and Chiara Vitale-Brovarone

University of Turin

Challenge

Osteoporosis and degradation of bone mechanics affects millions of people each year, often leading to fractures and immobility. Therefore, regenerative medicine strategies are urgently needed. Bioprinting complex geometries with collagen, however, can be challenging and most scaffolds based on type I collagen and hydroxyapatite are fabricated by freeze-drying or casting, application that give bioengineers limited control over the final shape and porosity of their constructs.

Solution

The team at the Polytechnic University of Turin mitigated these challenges by combining the BIO X, a temperature controlled printhead and gelatin-supporting baths (the FRESH method) to 3D bioprint taller, more complex bone scaffolds with type I collagen.

Results

The study validates the potential for collagen nanocomposites as a material for high-resolution 3D bioprinting. The authors also suggest that using the hybrid material represents a significant step toward fabricating biomimetic patient-specific bone-like scaffolds on demand.

Learn more

WATCH THE VIDEO HERE!

Synthesis and incorporation of rod-like nano-hydroxyapatite into type I collagen matrix: A hybrid formulation for 3D printing of bone scaffolds. Journal of the European Ceramic Society. 2020. DOI: 10.1016/j.jeurceramsoc.2020.02.018.

Silvia Pisani, Rossella Dorati, Franca Scocozza, et al

University of Pavia

Challenge

Typically, gelatin, collagen, alginate and fibrin hydrogels are used in 3D bioprinting and tissue engineering because of their extracellular matrix (ECM) properties. However, the search for other natural ECM-like polymers has lagged behind. Chitosan, a natural, biocompatible and biodegradable polymer, has been approved by the FDA and EMA for use in wound dressings, but it is not stable under physiological conditions.

Solution

Conti et al. discovered that because of their ionic interactions and rheological properties, 3D bioprinting of chitosan and gamma-PGA structures together at certain concentrations of the biopolymer and crosslinker resulted in more favorable constructs. The CELLINK INKREDIBLE+ bioprinter was used to explore the bioprinting properties of this bioink formulation in order to compare it to other natural ECM material formulations.

Results

The 3D structures generated by the INKREDIBLE+ confirmed that the chitosan-gamma-PGA formulation is biocompatible and stable under shear stresses greater than that of human arteries and veins.

Read more

Preliminary investigation on a new natural based poly(gamma‐glutamic acid)/chitosan bioink. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2020. DOI: 10.1002/jbm.b.34602.

Find out why 1,000+ labs around the world trust the BIO X and other revolutionary CELLINK systems to advance their research
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Bioprinter BIO X

Benefits at a glance

1


ALL INCLUDED

Turnkey solution: Hardware Software and consumables compatibility problems are just a memory

2


COMPACT FOOTPRINT

BOTH COMPRESSOR AND COOLING UNIT HAVE BEEN INTEGRATED WITHOUT COMPROMISING ITS SIZE

3


CLEAN CHAMBER FOR BETTER CELL VIABILITY

Built-in UV sterilization and a HEPA filter bring the sterility of the biosafety cabinet to the benchtop.

4


TARGET ON SIGHT

Reduction of failures and faster clinical trials

5


ALL INCLUDED

Turnkey solution: Hardware Software and consumables compatibility problems are just a memory

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